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  • 2020-05-30 魚油可以減少大腸習肉的癌症病變可能性

 直腸習肉的病理切片 by Nephron from wikipedia

 

                               Woman who eat fish have lower colon polyp risk


by  Dagny Stuart     from  Harvey Murff(Vanderbilt  University)        2012-02-09  

                    


Women who eat at least three servings of fish per week have a reduced risk of developing some types of colon polyps according to a new study by Vanderbilt-Ingram Cancer Center investigators.

The research, led by first author Harvey Murff, associate professor of medicine, was published online in the American Journal of Clinical Nutrition.

The VICC researchers believe that omega-3 fats in fish may reduce inflammation in the body and help protect against the development of colon polyps. Polyps are small growths on the lining of the intestinal tract that may develop into cancer.

Earlier research in animals has suggested a link between inflammation and colon polyp formation but studies in humans have not been conclusive.

Colorectal cancer is the fourth most common cancer and the second leading cause of cancer-related death in the United States.

More than 5,300 participants were enrolled in the Tennessee Colorectal Polyp Study and received colonoscopies at Vanderbilt or the Veterans’ Affairs Tennessee Valley Health System in Nashville. Study participants completed food frequency questionnaires to determine how often they ate fish and investigators obtained urine samples from some of the patients to measure biomarkers for a hormone related to inflammation.

Women who ate the equivalent of three servings of fish per week had about a 33 percent reduction in the risk for colon polyps. They also had a lower level of a hormone called prostaglandin E2, which is linked to inflammation.

“That was the aspect of the study we were particularly excited about because prostaglandin E2 is known to be associated with adenomas or polyps in colorectal cancers,” said Murff.

Murff said fish oil appears to have the same beneficial effect as aspirin in reducing inflammation and this may protect against the formation of polyps.


“Women who ate more fish had lower numbers of polyps and they had lower levels of prostaglandin E2 which reassured us that these results may be real findings and not just a statistical fluke,” Murff explained.

While women who ate the most fish saw some protective effect, men who ate more fish did not have a reduced risk of developing colon polyps.

The VICC investigators were surprised by this difference.

The difference between men and women may be linked to their background diet.“The difference between men and women may be linked to their background diet. Even though men are eating more omega-3 fatty acids they may also be eating more omega-6 fatty acids and that may be blunting the effect,” said Murff.

Omega-6 fatty acids which are found in meats, grains and seed oils, including corn, safflower and sunflower oil, may counteract the protective effect of omega-3 fatty acids.

While eating more fish appeared to be beneficial, not all types of fish contain high levels of the protective omega-3 fatty acids. Tuna, salmon and sardines are high in omega-3 acids, while tilapia and catfish have low levels.

To validate the findings from their study, the authors are currently conducting a clinical trial to determine the effect of fish oil supplementation and prostaglandin E2 production.

The National Cancer Institute funded the study through a series of research grants.


 

 

 

 

直腸癌症發生位置圖 by Blausen Medical communication,inc from wikipedia

 

 

                      魚油可以減少大腸習肉的癌症病變可能性 

翻譯自2012-02-09-美國梵德堡大學英格癌症研究中心哈威-莫菲醫學院教授的臨床研究結果

 

根據美國梵德堡大學英格癌症研究中心(VICC)的醫學院教授-哈威-莫菲的臨床研究結果:一個星期至少吃三次魚的女性朋友,俱有降低33%大腸息肉發生機率的可能性(本篇臨床研究結果已經刊登在美國臨床營養學期刊上)!這項臨床研究的主要內容為:超過5300個的男參與者,自願參與美國田納西州的直腸習肉臨床鏡檢研究計劃;這項臨床鏡檢研究計劃的步驟為,首先必須要完全追蹤記錄參與者攝取魚類食物的頻率次數,其次則是要的忠實檢測參與者的特定尿液賀爾蒙濃度(特定尿液賀爾蒙的濃度值在臨床上,和身體器官發炎反應,有著密不可分的因果關係;在美國直腸癌為發生率排名第四的癌症,然則卻是第二高致死率的癌症);結果顯現出一個驚人的答案:一個星期至少吃三次魚的女性參與者,俱有降低33%大腸息肉發生機率的可能性!此外在此項臨床研究實驗中也證實了另一項推論,一個星期至少吃三次魚的女性參與者,也同時普遍擁有較低的前列腺素E2濃度(前列腺素E2=Prostaglandin E2,為直腸癌發生的前趨性判斷因子)!

 

 

那麼為何多攝取魚類食物,就能大幅減少大腸習肉癌症病變可能性?按照美國梵德堡大學醫學院教授-哈威-莫菲的看法,魚油中的Omega-3不飽和脂肪酸(如DHA&EPA)似乎和阿斯匹靈的消炎作用有所類型?!而阿斯匹靈的消炎作用(阿斯匹靈本身還是有副作用的),已經被證明能夠降低大腸習肉的產生(大腸習肉本身是一種發炎現象)!只是另外一個問題是,為什麼同樣是吃魚(甚至於男性攝取更多的魚類食物),男性參與者的大腸習肉癌症病變比率,卻始終沒辦法像女性參與者一樣的慢慢降下來?要回答這個問題,可能要追溯到男性參與者所攝取的廣泛食物背景?依據美國梵德堡大學醫學院教授-哈威-莫菲的資料對比觀察分析,男性縱使是攝取了更多的魚類食物,然而無獨有偶的也享用了旗鼓相當的Omega-6脂肪酸來源食物(像是各種植物油,穀類種子,燒烤肉類等食物),以至於魚油中的Omega-3不飽和脂肪酸(如DHA&EPA)效用,早就被Omega-6脂肪酸給抵消殆盡!?而除了上述的理由之外,在本次的臨床研究中,也注意到一件事實,如果男性參與者在攝取魚類食物時,沒有慎選含有較高Omega-3不飽和脂肪酸成份的魚種來食用(如鮪魚,鮭魚,沙丁魚),則大腸習肉癌症病變可能性恐怕會更容易飆高?最後此次臨床研究報告的相關魚油消炎功能表現,仍將會由前列腺素E2的再次臨床檢測,來決定其理論的確認性!   

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