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  • 2021-10-30 魚油救了我們的兒子----part-2

 

        

Fish Oil Helped Save Our Son Extract from CNN 2012-10-19 Part-2


The brick wall analogy


That's the theory behind using omega-3 fatty acids to heal brain injury. The human brain, which itself is a fatty mass, is about 30% composed of omega-3 fatty acids, according to Lewis.

In his words, high doses of omega-3 fatty acids, since they mirror what is already in the brain, could facilitate the brain's own natural healing process.
"It really gets down to what I would call my brick wall analogy," Lewis said. "If you have a brick wall and it gets damaged, wouldn't you want to use bricks to repair the wall? And omega-3 fatty acids are literally the bricks of the cell wall in the brain."
Most of the studies about omega-3 for traumatic brain injury are in animals, but they indicate potential for healing the human brain.
After a trauma, the brain tends to swell, and the connections between some nerve cells can become damaged, while other cells simply die.
National Institutes of Health research suggests that omega-3 fatty acids may inhibit cell death and could be instrumental for reconnecting damaged neurons.
Another recent study revealed genes that are activated to contain massive damage -- especially inflammation -- when the brain is injured. What activates those genes: omega-3.
"We have strong data that suggest omega-3 will activate good proteins to cope with brain damage and turn off proteins that cause neuroinflammation," said Dr. Nicolas Bazan, director of the Neuroscience Center of Excellence at LSU Health in New Orleans and author of the study.
And besides that, according to Bailes and Lewis, fish oil may be the only solution for brain damage that continues after a traumatic brain injury patient has been stabilized.
"There is no known solution; there's no known drug; there's nothing that we have really to offer these sorts of patients," said Bailes, who along with Lewis received money from companies that make fish oil after their treatment of Ghassemi and McCloy.
The damage to McCloy's brain was profound, according to Bailes. Not only did it experience massive cell death, the protective sheath around McCloy's nerve cells had been stripped during the hours of exposure to toxic gases. That sheath, called myelin, allows brain cells to communicate with one another.
Bailes consulted with a fish oil expert and eventually decided that administering 20 grams a day of omega-3 fish oil through a feeding tube might repair the myelin sheath. (For comparison: A typical supplemental dose for someone with an uninjured brain is about 2 grams a day.)
"We decided to throw the kitchen sink at him," Bailes said. "If we were going to fail, we were going to fail with all guns blazing, so we gave him a very high, unprecedented dose to make sure we saturated and got high levels in the brain."
Less than three weeks after the mine disaster, McCloy was emerging from his coma. Three months after that, he was walking and speaking.
Citing McCloy's dramatic recovery, Lewis spoke with Peter Ghassemi about introducing omega-3 for his son. After that conversation, Peter Ghassemi was convinced and began to pressure his son's doctors.
"It was a fight," Peter Ghassemi said. "They didn't believe, and they said, 'Fine, the West Virginia miner was one case. Bring me 999 more cases, a thousand more cases ... before I can give it to your son.' "
But eventually they conceded, and Bobby Ghassemi was started on high-dose fish oil therapy, at a dosage that mirrored what Bailes had given to McCloy in 2006.


 
 
 

   

 

魚油救了我們的兒子  翻譯節錄自CNN   2012-10-19  Part-2

 

人類的腦部組織主要由脂肪所組成,平時可以透過攝取魚類脂肪酸(DHA&EPA),得到一定程度的實質助益,圖片乃DHA之立體結構圖

 

基本上醫治礦工雷恩-麥克的醫學治療理論,後來被比-斯密的主治醫師-麥可-路易士稱為是:磚牆理論;只是什麼又是磚牆理論?按照麥可-路易士醫師的解釋,人體的腦部組織,其實就是一個以脂肪為主體的器官(約佔了60%的腦部成份重量)!而腦部脂肪組織中的Omega-3不飽和脂肪酸(Ex:DHA&EPA,特別是DHA)就佔了有整個腦部脂肪組織其中的一半份量(60%乘以1/2=30%,換句話說Omega-3不飽和脂肪酸在整個腦部組織中的比例約為30%);所以說如果利用Omega-3不飽和脂肪酸來參與腦部組織的修護,可能是再適合不過的事(假設今天你有一道磚牆損壞了,你會要拿什樣的材料來進行修繕?是拿木頭?還是鋼條?當然是二者皆非!相反的,你只要選擇相同的磚塊予以回砌,不也就行了嗎)?!而且許多美國本土的動物性的實驗結果也顯示,補充Omega-3不飽和脂肪酸,的確可以醫療動物的腦部傷害症狀;另外依照美國國家健康研究中心的說法也指出:Omega-3不飽和脂肪酸不但可以有效抑制腦部神經組織的壞死,還能夠把受損的腦部神經細胞給予重新的活化連結(以礦工雷恩-麥克的情形為例,有毒的氣體最終會侵蝕掉腦神經細胞的外鞘,使得負責神經細胞突觸(Synapse)的細胞外鞘解體,造成神經細胞彼此無法相互連接;不過如果能給予足夠的Omega-3不飽和脂肪酸,受損之神經細胞外鞘(Myelin),或許還可以恢復連結功能)!

 

嗜吃牛肉的老美已有越來越多的人開始食用魚類食物耶,且發現受益良多咧,照片魚種係大西洋鮭.

  

    此外紐奧良神經科學研究中心的尼可拉斯-巴璋博士也公開發表意見,認為Omega-3不飽和脂肪酸具有對抗腦部發炎組織中之良性蛋白質之啟動能力;同時從神經外科主治醫師-茱莉安-貝理麥可-路易士醫師的臨床經驗中也顯示,Omega-3不飽和脂肪酸似乎是腦部組織受損後的惟一有效解答,遠非任何的藥物所能取代!所以在稍早治療礦工雷恩-麥克的案例中,神經外科主治醫師-茱莉安-貝理絲所領導的醫療團隊在和魚油專家商議後,為了爭取時效,毅然而果斷的決定讓礦工雷恩-麥克羅一天攝取20克左右的Omega-3不飽和脂肪酸魚油(對於未受傷的腦部組織保養,在美國的魚油建議用量為每天攝取2克(2000MG)左右的Omega-3不飽和脂肪酸魚油)來遏止腦部脂肪組織的持續惡化!結果是3個星期還不到的時間過去了,年輕的礦工雷恩-麥克羅首度由昏迷中甦醒過來!而再過了3個月的治療時間,雷恩-麥克羅已經能走路和說話!不過令人遺憾的是,縱使礦工雷恩-麥克羅的復原情形是如此的顯著,可是比-斯密的父親卻反覆的無法接受自己兒子主治醫師的使用魚油建議!?開什麼玩笑?礦工雷恩-麥克羅的案例又如何?有沒有更多的999個案例能夠證明魚油的真正價值?!我無法接受讓自己的兒子來冒險使用魚油?魚油又有什能耐?然而抱怨歸抱怨,真誠的麥可-路易士主治醫師最終還是說服了比-斯密的父親!比-斯密開始接受了和礦工雷恩-麥克羅一樣的高劑量Omega-3不飽和脂肪酸魚油之治療方式!

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